GCT: a genetic compatibility test
Thanks to this innovative analysis, we can anticipate and avoid the transmission of over 600 genetic diseases from parents to offspring
How can we help you?
Most people are healthy carriers of one recessive disorder or another. If a person's partner is also a carrier of the same gene mutation, there is a 25% risk of the couple's child having that illness and a 50% risk of the child being a healthy carrier of it, meaning that there could also be implications for the child's family in the future.
What is a genetic compatibility test?
It is an innovative analysis that tells us if there is a risk of the future parents transmitting any of the 600 most common genetic recessive disorders to their future offspring. As such, it is possible to avoid them being passed on.
At IB BIOTECH, we are experts in genetic diagnosis using the very latest technology. We have leading sequencers (Illumina ®) and a highly qualified team of human resources.
Nowadays, next generation DNA sequencing (NGS) is a fundamental tool in genetic diagnosis of human hereditary disorders that consists of complete clinical exome sequencing and specific gene sequencing panels for specific illnesses.
The carrier test that is performed at IB BIOTECH is one of the most comprehensive that exists given that it facilitates analysis of over 600 recessive disorders.
How is the genetic compatibility test (GCT) performed?
Using a blood sample some both parents, it is possible to extract the necessary DNA for performing the test. It takes around two weeks to complete a DNA and bioinformatic analysis that enables us to determine if the genetic variants that have been identified have an impact on clinical outcomes and, as such, are a risk to offspring. The report that is written based on the data obtained in the analysis needs to be compared with the one for the other parent in order to understand if both partners have mutated genes and if there is a real risk of transmitting the illness.
What are its advantages?
- Prevention: It is better to prevent than cure. The knowledge that parents (whether these are partners or gamete donors) are carriers of a recessive genetic disorder avoids transmission of that disorder to offspring.
- Increased knowledge and assurance: Up until now, the available techniques only facilitated analysis of a very limited number of genes. As such, they had a very limited cost/advantage ratio. The number of genes that are analysed increases in next generation sequencing techniques and this guarantees the patient that he or she will have a child that is free of more than 600 genetic disorders.
- Less costly: in comparison with traditional techniques, next generation sequencing allows us to understand a larger number of genes at a lower cost. The genetic information that it provides can be put to use throughout a patient’s life and can be used from a conception point of view for additional children in the future.
When is it appropriate to perform a GCT?
- Couples who are due to undergo assisted reproduction treatment entailing added physical, emotional and financial exertion and couples wish to ensure that their child will be born healthy.
- In assisted reproduction treatment using donated gametes, gamete quality is an absolute priority and carrying out the test is, therefore, a means of providing this guarantee.
- Any couple that is searching for preconception counselling that gives them the guarantee, before they get pregnant, that their future child will not have any of the 600 most common recessive disorders.