IBBIOTECH

Experiencia y futuro en biotecnología

Breast cancer genetic study

Please request a personalize kit fir the test

1 in 8 women will suffer from breast cancer along our lives, and most of them have a hereditary component. Thanks to genetics we can study if we have the predisposition and we can take the appropiate preventive measures. IB BIOTECH is a pioneer centre in thestudy of linked genes.

Genetic is an essential tool in Medicine since a considerable percentage of human health problems have a hereditary component. Any genetic based illness can be diagnosed through molecular biology techniques.

Most kinds of breast cancer are sporadic cancer, that is, there are no signs of hereditary susceptibility of suffering the illness. But here is a proportion; it is estimated to be around 10%, where there is a hereditary predisposition to suffering cancer. One third hereditary breast cancer is due to a mutation in BRCA1, other third are due to mutations in BRCA2 and the rest are due to other genes. Breast cancer associated to BRCA1 mutations show up at the pre-menopause (around 42 years of age) and the contra lateral breast cancer rate after five years is approximately of 30% in women carrying the BRCA1 mutation. The BRCA2 genetic alterations are linked to masculine breast cancer.

Next we explain some situation when is useful to do this kind of study:

Families with only one case of breast cancer
Bilateral primary breast cancer before the age of 40.
Breast cancer before the age of 30.
Breast and ovary cancer in the same patient.
Families with two cancer cases in first grade family members:
Two breast cancer being diagnose, at least one f them before the age of 50 or bilateral.
Two or more cases of ovary cancer.
One breast cancer and ovary cancer in two family members.
One breast cancer case in a woman and one breast cancer case in a male.
Families with three or more breast cancer affected members, at least two in first grade family members (mothers, daughters or sisters).

For a specific assessment of your illness you can request an appointment or if you can’t come to our clinic you can request an on-line medical appointment or directly do test in the comfort of your home. Please request a personalize kit for the test.

IB Biotech offers two leves of study of the BRCA1 and 2 gene mutation:

Complete sequence of the codified regions of the BRCA1 and/or 2 gene.
Study of the most frequent mutations. Where we analyze the most prevalent mutation in the 50% of cases with alterations in those genes:
*BRCA1: 187-188delAG; 330A>G; 5236G>A; 5242C>A y 589-590delCT.
*BRCA2: 3036-3039del ACAA; 6857-6858delAA; 9254-9258del5; 9538-3539delAA y 5374-5377delTATG.

The test

The test to determine if a person is affected by an illness it can be done, preferable, through a blood test, and you can also request a kit to take the samples at home, in this case you will need to take a sample through an oral smear test.

The procedure is very simple. In the kit you will receive, you will find a sterilize cotton/wool tip, with which you will need to rub the inside part of your mouth. Please handle the samples with care. Do not touch the cotton-wool tips with the fingers. Once you have taken the sample and packed away appropriately, as shown in the instructions, you will send it to us together with appropriate filled in forms you received with the kit.

Please request a personalize kit fir the test

Obtaining the sample at home