IBBIOTECH

Experiencia y futuro en biotecnología

TUNEL: Dna fragmentation in spermatozoids

It consist in the determination on the spermatic DNA fragmentation through the technique called TUNEL. It has been proved that infertile males have a major fraction of spermatozoids with fractures in the DNA and that could have a negative impact in the result of assisted reproduction.

The techniqe that we use to determine espermatic DNA fragmentation is TUNEL or Terminal dUTP Nick-End Labeling that consists on measuring broken DNA chains incorporating molecules fluorecently marked.

An increase in the spermatozoid population with fragmented DNA could be reponsable of implantation failure and miscarriges.

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